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Sequence-based design of bioactive small molecules that target precursor microRNAs
Oligonucleotides are designed to target RNA using base pairing rules, however, they are hampered by poor cellular delivery and non-specific stimulation of the immune system. Small molecules are preferred as lead drugs or probes, but cannot be designed from sequence. Herein, we describe an approach t...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3962094/ https://ncbi.nlm.nih.gov/pubmed/24509821 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1452 |
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