A mouse collagen4α4 mutation causing Alport glomerulosclerosis with abnormal collagen α3α4α5(IV) trimers

A spontaneous mutation termed bilateral wasting kidneys (bwk) was identified in a colony of NONcNZO recombinant inbred mice. These mice exhibit a rapid increase of urinary albumin at an early age associated with glomerulosclerosis, interstitial nephritis, and tubular atrophy. The mutation was mapped...

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Hauptverfasser: Korstanje, Ron, Caputo, Christina, Doty, Rosalinda, Cook, Susan, Bronson, Roderick, Davisson, Muriel, Miner, Jeffrey H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040157/
https://ncbi.nlm.nih.gov/pubmed/24522496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2013.493
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