Identification of Noncollagenous Sites Encoding Specific Interactions and Quaternary Assembly of α3α4α5(IV) Collagen: IMPLICATIONS FOR ALPORT GENE THERAPY

Defective assembly of α3α4α5(IV) collagen in the glomerular basement membrane causes Alport syndrome, a hereditary glomerulonephritis progressing to end-stage kidney failure. Assembly of collagen IV chains into heterotrimeric molecules and networks is driven by their noncollagenous (NC1) domains, bu...

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Detalhes bibliográficos
Main Authors: Kang, Jeong Suk, Colon, Selene, Hellmark, Thomas, Sado, Yoshikazu, Hudson, Billy G., Borza, Dorin-Bogdan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2596392/
https://ncbi.nlm.nih.gov/pubmed/18930919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806396200
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