A Human-Mouse Chimera of the α3α4α5(IV) Collagen Protomer Rescues the Renal Phenotype in Col4a3(−/−) Alport Mice

Collagen IV is a major structural component of basement membranes. In the glomerular basement membrane (GBM) of the kidney, the α3, α4, and α5(IV) collagen chains form a distinct network that is essential for the long-term stability of the glomerular filtration barrier, and is absent in most patient...

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Hauptverfasser: Heidet, Laurence, Borza, Dorin-Bogdan, Jouin, Mélanie, Sich, Mireille, Mattei, Marie-Geneviève, Sado, Yoshikazu, Hudson, Billy G., Hastie, Nicholas, Antignac, Corinne, Gubler, Marie-Claire
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2003
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868284/
https://ncbi.nlm.nih.gov/pubmed/14507670
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