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A Human-Mouse Chimera of the α3α4α5(IV) Collagen Protomer Rescues the Renal Phenotype in Col4a3(−/−) Alport Mice
Collagen IV is a major structural component of basement membranes. In the glomerular basement membrane (GBM) of the kidney, the α3, α4, and α5(IV) collagen chains form a distinct network that is essential for the long-term stability of the glomerular filtration barrier, and is absent in most patient...
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| Hlavní autoři: | , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Investigative Pathology
2003
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1868284/ https://ncbi.nlm.nih.gov/pubmed/14507670 |
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