Transfer of the α5(IV) Collagen Chain Gene to Smooth Muscle Restores in Vivo Expression of the α6(IV) Collagen Chain in a Canine Model of Alport Syndrome

X-linked Alport syndrome is a progressive renal disease caused by mutations in the COL4A5 gene, which encodes the α5(IV) collagen chain. As an initial step toward gene therapy for Alport syndrome, we report on the expression of recombinant α5(IV) collagen in vitro and in vivo. A full-length cDNA-enc...

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Huvudupphovsmän: Harvey, Scott J., Zheng, Keqin, Jefferson, Barbara, Moak, Peter, Sado, Yoshikazu, Naito, Ichiro, Ninomiya, Yoshifumi, Jacobs, Robert, Thorner, Paul S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Investigative Pathology 2003
Ämnen:
Regular Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868105/
https://ncbi.nlm.nih.gov/pubmed/12598321
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