Co-targeting the MAPK and PI3K/AKT/mTOR pathways in two genetically engineered mouse models of schwann cell tumors reduces tumor grade and multiplicity

Malignant peripheral nerve sheath tumors (MPNSTs) are soft tissue sarcomas that occur spontaneously, or from benign plexiform neurofibromas, in the context of the genetic disorder Neurofibromatosis Type 1 (NF1). The current standard treatment includes surgical resection, high-dose chemotherapy, and/...

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Main Authors: Watson, Adrienne L., Anderson, Leah K., Greeley, Andrew D., Keng, Vincent W., Rahrmann, Eric P., Halfond, Amanda L., Powell, Natasha M., Collins, Margaret H., Rizvi, Tilat, Moertel, Christopher L., Ratner, Nancy, Largaespada, David A.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2014
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039227/
https://ncbi.nlm.nih.gov/pubmed/24681606
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