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Using ‘biased-privileged’ scaffolds to identify lysine methyltransferase inhibitors
Methylation of histones by lysine methyltransferases (KMTases) plays important roles in regulating chromatin function. It is also now clear that improper KMTases activity is linked to human diseases, such as cancer. We report an approach that employs drug-like ‘privileged’ scaffolds biased with moti...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4038709/ https://ncbi.nlm.nih.gov/pubmed/24650704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2014.02.024 |
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