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Examining the mechanism of action of a kinesin inhibitor using Stable Isotope Labeled Inhibitors for Crosslinking (SILIC)
It is difficult to determine a chemical inhibitor’s binding site in multi-protein mixtures, particularly when high-resolution structural studies are not straightforward. Building upon previous research involving photo-crosslinking and the use of mixtures of stable isotopes, we report a method, Stabl...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3309614/ https://ncbi.nlm.nih.gov/pubmed/21761885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja204561q |
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