PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix

Loss-of-function mutations in PINK1, which encodes a mitochondrially targeted serine/threonine kinase, result in an early-onset heritable form of Parkinson's disease. Previous work has shown that PINK1 is constitutively degraded in healthy cells, but selectively accumulates on the surface of de...

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Bibliografiske detaljer
Main Authors: Thomas, Ruth E., Andrews, Laurie A., Burman, Jonathon L., Lin, Wen-Yang, Pallanck, Leo J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038460/
https://ncbi.nlm.nih.gov/pubmed/24874806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004279
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