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P2X(7) Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway

OBJECTIVE: The NLRP3 inflammasome plays key roles in inflammation and autoimmunity, and puriner-gic receptor P2X(7) has been proposed to be upstream of NLRP3 activation. The aim of the present study, using murine models, was to investigate whether the P2X(7)/ NLRP3 inflammasome pathway contributes t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhao, Jijun, Wang, Hongyue, Dai, Chao, Wang, Hongyang, Zhang, Hui, Huang, Yuefang, Wang, Shuang, Gaskin, Felicia, Yang, Niansheng, Fu, Shu Man
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038356/
https://ncbi.nlm.nih.gov/pubmed/24022661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38174
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