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P2X(7) Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway
OBJECTIVE: The NLRP3 inflammasome plays key roles in inflammation and autoimmunity, and puriner-gic receptor P2X(7) has been proposed to be upstream of NLRP3 activation. The aim of the present study, using murine models, was to investigate whether the P2X(7)/ NLRP3 inflammasome pathway contributes t...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4038356/ https://ncbi.nlm.nih.gov/pubmed/24022661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.38174 |
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