A Dwarf Mouse Model With Decreased GH/IGF-1 Activity That Does Not Experience Life-Span Extension: Potential Impact of Increased Adiposity, Leptin, and Insulin With Advancing Age

Reduced growth hormone (GH) action is associated with extended longevity in many vertebrate species. GH receptor (GHR) null (GHR(−)(/−)) mice, which have a disruption in the GHR gene, are a well-studied example of mice that are insulin sensitive and long lived yet obese. However, unlike other mouse...

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Detaylı Bibliyografya
Asıl Yazarlar: Berryman, Darlene E., Lubbers, Ellen R., Magon, Vishakha, List, Edward O., Kopchick, John J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2014
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038240/
https://ncbi.nlm.nih.gov/pubmed/23695394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glt069
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