Molecular Stress-inducing Compounds Increase Osteoclast Formation in a Heat Shock Factor 1 Protein-dependent Manner

Many anticancer therapeutic agents cause bone loss, which increases the risk of fractures that severely reduce quality of life. Thus, in drug development, it is critical to identify and understand such effects. Anticancer therapeutic and HSP90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin (17-A...

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Autori principali: Chai, Ryan C., Kouspou, Michelle M., Lang, Benjamin J., Nguyen, Chau H., van der Kraan, A. Gabrielle J., Vieusseux, Jessica L., Lim, Reece C., Gillespie, Matthew T., Benjamin, Ivor J., Quinn, Julian M. W., Price, John T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036365/
https://ncbi.nlm.nih.gov/pubmed/24692538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.530626
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