Histone deacetylase activity mediates acquired resistance towards structurally diverse HSP90 inhibitors

Heat shock protein 90 (HSP90) regulates multiple signalling pathways critical for tumour growth. As such, HSP90 inhibitors have been shown to act as effective anticancer agents in preclinical studies but, for a number of reasons, the same effect has not been observed in the clinical trials to date....

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Bibliographic Details
Published in:Mol Oncol
Main Authors: Chai, Ryan C., Vieusseux, Jessica L., Lang, Benjamin J., Nguyen, Chau H., Kouspou, Michelle M., Britt, Kara L., Price, John T.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527463/
https://ncbi.nlm.nih.gov/pubmed/28306192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12054
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