Histone deacetylase activity mediates acquired resistance towards structurally diverse HSP90 inhibitors

Heat shock protein 90 (HSP90) regulates multiple signalling pathways critical for tumour growth. As such, HSP90 inhibitors have been shown to act as effective anticancer agents in preclinical studies but, for a number of reasons, the same effect has not been observed in the clinical trials to date....

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Publicat a:Mol Oncol
Autors principals: Chai, Ryan C., Vieusseux, Jessica L., Lang, Benjamin J., Nguyen, Chau H., Kouspou, Michelle M., Britt, Kara L., Price, John T.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527463/
https://ncbi.nlm.nih.gov/pubmed/28306192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12054
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