Histone deacetylase activity mediates acquired resistance towards structurally diverse HSP90 inhibitors

Heat shock protein 90 (HSP90) regulates multiple signalling pathways critical for tumour growth. As such, HSP90 inhibitors have been shown to act as effective anticancer agents in preclinical studies but, for a number of reasons, the same effect has not been observed in the clinical trials to date....

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Bibliografiska uppgifter
I publikationen:Mol Oncol
Huvudupphovsmän: Chai, Ryan C., Vieusseux, Jessica L., Lang, Benjamin J., Nguyen, Chau H., Kouspou, Michelle M., Britt, Kara L., Price, John T.
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2017
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527463/
https://ncbi.nlm.nih.gov/pubmed/28306192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12054
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