Histone deacetylase activity mediates acquired resistance towards structurally diverse HSP90 inhibitors

Heat shock protein 90 (HSP90) regulates multiple signalling pathways critical for tumour growth. As such, HSP90 inhibitors have been shown to act as effective anticancer agents in preclinical studies but, for a number of reasons, the same effect has not been observed in the clinical trials to date....

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Chai, Ryan C., Vieusseux, Jessica L., Lang, Benjamin J., Nguyen, Chau H., Kouspou, Michelle M., Britt, Kara L., Price, John T.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527463/
https://ncbi.nlm.nih.gov/pubmed/28306192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12054
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