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Histone deacetylase activity mediates acquired resistance towards structurally diverse HSP90 inhibitors
Heat shock protein 90 (HSP90) regulates multiple signalling pathways critical for tumour growth. As such, HSP90 inhibitors have been shown to act as effective anticancer agents in preclinical studies but, for a number of reasons, the same effect has not been observed in the clinical trials to date....
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| Published in: | Mol Oncol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
John Wiley and Sons Inc.
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5527463/ https://ncbi.nlm.nih.gov/pubmed/28306192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12054 |
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