Molecular Stress-inducing Compounds Increase Osteoclast Formation in a Heat Shock Factor 1 Protein-dependent Manner

Many anticancer therapeutic agents cause bone loss, which increases the risk of fractures that severely reduce quality of life. Thus, in drug development, it is critical to identify and understand such effects. Anticancer therapeutic and HSP90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin (17-A...

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Main Authors: Chai, Ryan C., Kouspou, Michelle M., Lang, Benjamin J., Nguyen, Chau H., van der Kraan, A. Gabrielle J., Vieusseux, Jessica L., Lim, Reece C., Gillespie, Matthew T., Benjamin, Ivor J., Quinn, Julian M. W., Price, John T.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036365/
https://ncbi.nlm.nih.gov/pubmed/24692538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.530626
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