The Arg-62 Residues of the TREX1 Exonuclease Act Across the Dimer Interface Contributing to Catalysis in the Opposing Protomers

TREX1 is a 3′-deoxyribonuclease that degrades single- and double-stranded DNA (ssDNA and dsDNA) to prevent inappropriate nucleic acid-mediated immune activation. More than 40 different disease-causing TREX1 mutations have been identified exhibiting dominant and recessive genetic phenotypes in a spec...

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Bibliografiske detaljer
Main Authors: Fye, Jason M., Coffin, Stephanie R., Orebaugh, Clinton D., Hollis, Thomas, Perrino, Fred W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036290/
https://ncbi.nlm.nih.gov/pubmed/24616097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.559252
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