The TREX1 C-terminal Region Controls Cellular Localization through Ubiquitination

TREX1 is an autonomous 3′-exonuclease that degrades DNA to prevent inappropriate immune activation. The TREX1 protein is composed of 314 amino acids; the N-terminal 242 amino acids contain the catalytic domain, and the C-terminal region (CTR) localizes TREX1 to the cytosolic compartment. In this stu...

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Detalhes bibliográficos
Main Authors: Orebaugh, Clinton D., Fye, Jason M., Harvey, Scott, Hollis, Thomas, Wilkinson, John C., Perrino, Fred W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789983/
https://ncbi.nlm.nih.gov/pubmed/23979357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.503391
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