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The TREX1 C-terminal Region Controls Cellular Localization through Ubiquitination
TREX1 is an autonomous 3′-exonuclease that degrades DNA to prevent inappropriate immune activation. The TREX1 protein is composed of 314 amino acids; the N-terminal 242 amino acids contain the catalytic domain, and the C-terminal region (CTR) localizes TREX1 to the cytosolic compartment. In this stu...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3789983/ https://ncbi.nlm.nih.gov/pubmed/23979357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.503391 |
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