Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B cell lymphoma: Implications for epigenetic therapy

Protein tyrosine phosphatases such as PTPN6 can be downregulated in various neoplasms. PTPN6 expression by immunohistochemistry in 40 diffuse large B-cell lymphoma (DLBCL) tumors was lost or suppressed in 53% (21/40). To elucidate the molecular mechanisms of PTPN6 suppression we performed a comprehe...

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Detalhes bibliográficos
Main Authors: Witzig, Thomas E., Hu, Guangzhen, Offer, Steven M., Wellik, Linda E., Han, Jing Jing, Stenson, Mary J., Dogan, Ahmet, Diasio, Robert B., Gupta, Mamta
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036221/
https://ncbi.nlm.nih.gov/pubmed/23979523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.251
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