Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma

PTPN6 (SHP1) is a tyrosine phosphatase that negatively controls the activity of multiple signaling pathways including STAT signaling, however role of mutated PTPN6 is not much known. Here we investigated whether PTPN6 might also be a potential target for diffuse large B cell lymphoma (DLBCL) and per...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Demosthenous, Christos, Han, Jing Jing, Hu, Guangzhen, Stenson, Mary, Gupta, Mamta
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2015
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792586/
https://ncbi.nlm.nih.gov/pubmed/26565811
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