Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma

PTPN6 (SHP1) is a tyrosine phosphatase that negatively controls the activity of multiple signaling pathways including STAT signaling, however role of mutated PTPN6 is not much known. Here we investigated whether PTPN6 might also be a potential target for diffuse large B cell lymphoma (DLBCL) and per...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Demosthenous, Christos, Han, Jing Jing, Hu, Guangzhen, Stenson, Mary, Gupta, Mamta
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792586/
https://ncbi.nlm.nih.gov/pubmed/26565811
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