Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma

PTPN6 (SHP1) is a tyrosine phosphatase that negatively controls the activity of multiple signaling pathways including STAT signaling, however role of mutated PTPN6 is not much known. Here we investigated whether PTPN6 might also be a potential target for diffuse large B cell lymphoma (DLBCL) and per...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Demosthenous, Christos, Han, Jing Jing, Hu, Guangzhen, Stenson, Mary, Gupta, Mamta
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2015
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4792586/
https://ncbi.nlm.nih.gov/pubmed/26565811
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