Mitochondrial Dysfunction and Decrease in Body Weight of a Transgenic Knock-in Mouse Model for TDP-43

The majority of amyotrophic lateral sclerosis (ALS) cases as well as many patients suffering from frontotemporal lobar dementia (FTLD) with ubiquitinated inclusion bodies show TDP-43 pathology, the protein encoded by the TAR DNA-binding protein (Tardbp) gene. We used recombinase-mediated cassette ex...

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Main Authors: Stribl, Carola, Samara, Aladin, Trümbach, Dietrich, Peis, Regina, Neumann, Manuela, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabě de Angelis, Martin, Rathkolb, Birgit, Wolf, Eckhard, Beckers, Johannes, Horsch, Marion, Neff, Frauke, Kremmer, Elisabeth, Koob, Sebastian, Reichert, Andreas S., Hans, Wolfgang, Rozman, Jan, Klingenspor, Martin, Aichler, Michaela, Walch, Axel Karl, Becker, Lore, Klopstock, Thomas, Glasl, Lisa, Hölter, Sabine M., Wurst, Wolfgang, Floss, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036193/
https://ncbi.nlm.nih.gov/pubmed/24515116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.515940
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