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Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice

Sphingolipids and the derived gangliosides have critical functions in spermatogenesis, thus mutations in genes involved in sphingolipid biogenesis are often associated with male infertility. We have generated a transgenic mouse line carrying an insertion in the sphingomyelin synthase gene Sms1, the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wittmann, Anke, Grimm, Marcus O. W., Scherthan, Harry, Horsch, Marion, Beckers, Johannes, Fuchs, Helmut, Gailus-Durner, Valerie, Hrabě de Angelis, Martin, Ford, Steven J., Burton, Neal C., Razansky, Daniel, Trümbach, Dietrich, Aichler, Michaela, Walch, Axel Karl, Calzada-Wack, Julia, Neff, Frauke, Wurst, Wolfgang, Hartmann, Tobias, Floss, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082796/
https://ncbi.nlm.nih.gov/pubmed/27788151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164298
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