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Structure of the Toll-Spätzle complex, a molecular hub in Drosophila development and innate immunity

Drosophila Toll receptors are involved in embryonic development and the immune response of adult flies. In both processes, the only known Toll receptor ligand is the human nerve growth factor-like cystine knot protein Spätzle. Here we present the crystal structure of a 1:1 (nonsignaling) complex of...

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Bibliografski detalji
Glavni autori: Parthier, Christoph, Stelter, Marco, Ursel, Christian, Fandrich, Uwe, Lilie, Hauke, Breithaupt, Constanze, Stubbs, Milton T.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036000/
https://ncbi.nlm.nih.gov/pubmed/24733933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320678111
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