Expression and glycoengineering of functionally active heteromultimeric IgM in plants

IgM antibodies are an important player of the human’s innate defense mechanisms and increasingly have gained interest as therapeutics. Although the expression of IgM antibodies in mammalian cell culture is established, this approach remains costly and alternative methods have not been developed yet....

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Autors principals: Loos, Andreas, Gruber, Clemens, Altmann, Friedrich, Mehofer, Ulrich, Hensel, Frank, Grandits, Melanie, Oostenbrink, Chris, Stadlmayr, Gerhard, Furtmüller, Paul G., Steinkellner, Herta
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035941/
https://ncbi.nlm.nih.gov/pubmed/24706782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320544111
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