Impact of detubulation on force and kinetics of cardiac muscle contraction

Action potential–driven Ca(2+) currents from the transverse tubules (t-tubules) trigger synchronous Ca(2+) release from the sarcoplasmic reticulum of cardiomyocytes. Loss of t-tubules has been reported in cardiac diseases, including heart failure, but the effect of uncoupling t-tubules from the sarc...

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Autori principali: Ferrantini, Cecilia, Coppini, Raffaele, Sacconi, Leonardo, Tosi, Benedetta, Zhang, Mei Luo, Wang, Guo Liang, de Vries, Ewout, Hoppenbrouwers, Ernst, Pavone, Francesco, Cerbai, Elisabetta, Tesi, Chiara, Poggesi, Corrado, ter Keurs, Henk E.D.J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2014
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035744/
https://ncbi.nlm.nih.gov/pubmed/24863933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311125
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