Defects in T-tubular electrical activity underlie local alterations of calcium release in heart failure

Action potentials (APs), via the transverse axial tubular system (TATS), synchronously trigger uniform Ca(2+) release throughout the cardiomyocyte. In heart failure (HF), TATS structural remodeling occurs, leading to asynchronous Ca(2+) release across the myocyte and contributing to contractile dysf...

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Autors principals: Crocini, Claudia, Coppini, Raffaele, Ferrantini, Cecilia, Yan, Ping, Loew, Leslie M., Tesi, Chiara, Cerbai, Elisabetta, Poggesi, Corrado, Pavone, Francesco S., Sacconi, Leonardo
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210349/
https://ncbi.nlm.nih.gov/pubmed/25288764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411557111
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