CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells

BACKGROUND: Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene lead to the disease cystic fibrosis (CF). Although patients with CF often have disturbances in glucose metabolism including impaired insulin release, no previous studies have tested the hypothesis that CFTR...

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Hauptverfasser: Edlund, Anna, Esguerra, Jonathan LS, Wendt, Anna, Flodström-Tullberg, Malin, Eliasson, Lena
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035698/
https://ncbi.nlm.nih.gov/pubmed/24885604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-12-87
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