CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells

BACKGROUND: Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene lead to the disease cystic fibrosis (CF). Although patients with CF often have disturbances in glucose metabolism including impaired insulin release, no previous studies have tested the hypothesis that CFTR...

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Main Authors: Edlund, Anna, Esguerra, Jonathan LS, Wendt, Anna, Flodström-Tullberg, Malin, Eliasson, Lena
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2014
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035698/
https://ncbi.nlm.nih.gov/pubmed/24885604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-12-87
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