Combination cytotoxicity of backbone degradable HPMA copolymer gemcitabine and platinum conjugates toward human ovarian carcinoma cells

Multiblock, backbone degradable HPMA copolymer-drug conjugates containing gemcitabine and DACH platinum (mP-GEM and mP-DACH Pt), respectively were synthesized by reversible addition fragmentation (RAFT) polymerization and subsequent chain extension by click chemistry. Using combination index analysi...

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Main Authors: Duangjai, Acharaporn, Luo, Kui, Zhou, Yan, Yang, Jiyuan, Kopeček, Jindřich
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035385/
https://ncbi.nlm.nih.gov/pubmed/24316339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejpb.2013.11.008
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