Differentiation of immortal cells inhibits telomerase activity.

Telomerase, a ribonucleic acid-protein complex, adds hexameric repeats of 5'-TTAGGG-3' to the ends of mammalian chromosomal DNA (telomeres) to compensate for the progressive loss that occurs with successive rounds of DNA replication. Although somatic cells do not express telomerase, germ c...

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Bibliographic Details
Main Authors: Sharma, H W, Sokoloski, J A, Perez, J R, Maltese, J Y, Sartorelli, A C, Stein, C A, Nichols, G, Khaled, Z, Telang, N T, Narayanan, R
Format: Artigo
Language:Inglês
Published: 1995
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC40353/
https://ncbi.nlm.nih.gov/pubmed/8618897
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