Differentiation of immortal cells inhibits telomerase activity.

Telomerase, a ribonucleic acid-protein complex, adds hexameric repeats of 5'-TTAGGG-3' to the ends of mammalian chromosomal DNA (telomeres) to compensate for the progressive loss that occurs with successive rounds of DNA replication. Although somatic cells do not express telomerase, germ cells and i...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Sharma, H W, Sokoloski, J A, Perez, J R, Maltese, J Y, Sartorelli, A C, Stein, C A, Nichols, G, Khaled, Z, Telang, N T, Narayanan, R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40353/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8618897/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.26.12343
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