The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds

The PWWP domain is a weakly conserved sequence motif found in >60 eukaryotic proteins, including the mammalian DNA methyltransferases Dnmt3a and Dnmt3b. These proteins often contain other chromatin-association domains. A 135-residue PWWP domain from mouse Dnmt3b (amino acids 223–357) has been str...

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Bibliographic Details
Main Authors: Qiu, Chen, Sawada, Ken, Zhang, Xing, Cheng, Xiaodong
Format: Artigo
Language:Inglês
Published: 2002
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035047/
https://ncbi.nlm.nih.gov/pubmed/11836534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsb759
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