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Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment

Intratumoral hypoxia induces the recruitment of stromal cells, such as macrophages and mesenchymal stem cells (MSCs), which stimulate invasion and metastasis by breast cancer cells (BCCs). Production of macrophage colony-stimulating factor 1 (CSF1) by BCCs is required for macrophage recruitment, but...

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Hlavní autoři: Chaturvedi, Pallavi, Gilkes, Daniele M., Takano, Naoharu, Semenza, Gregg L.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034192/
https://ncbi.nlm.nih.gov/pubmed/24799675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1406655111
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