Hypoxia-inducible factor–dependent breast cancer–mesenchymal stem cell bidirectional signaling promotes metastasis

Metastasis involves critical interactions between cancer and stromal cells. Intratumoral hypoxia promotes metastasis through activation of hypoxia-inducible factors (HIFs). We demonstrate that HIFs mediate paracrine signaling between breast cancer cells (BCCs) and mesenchymal stem cells (MSCs) to pr...

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Detalhes bibliográficos
Main Authors: Chaturvedi, Pallavi, Gilkes, Daniele M., Wong, Carmen Chak Lui, Kshitiz, Luo, Weibo, Zhang, Huafeng, Wei, Hong, Takano, Naoharu, Schito, Luana, Levchenko, Andre, Semenza, Gregg L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533298/
https://ncbi.nlm.nih.gov/pubmed/23318994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64993
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