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Allosteric Modulation of Muscarinic Acetylcholine Receptors

An allosteric modulator is a ligand that binds to an allosteric site on the receptor and changes receptor conformation to produce increase (positive cooperativity) or decrease (negative cooperativity) in the binding or action of an orthosteric agonist (e.g., acetylcholine). Since the identification...

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Autori principali: Jakubík, Jan, El-Fakahany, Esam E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034100/
https://ncbi.nlm.nih.gov/pubmed/27713379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph3092838
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