Design, Synthesis, and Biological Evaluation of O-2-Modified Indenoisoquinolines as Dual Topoisomerase I–Tyrosyl-DNA Phosphodiesterase I Inhibitors

[Image: see text] Tyrosyl-DNA phosphodiesterase I (TDP1) repairs stalled topoisomerase I (Top1)–DNA covalent complexes and has been proposed to be a promising and attractive target for cancer treatment. Inhibitors of TDP1 could conceivably act synergistically with Top1 inhibitors and thereby potenti...

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Bibliographic Details
Main Authors: Lv, Peng-Cheng, Agama, Keli, Marchand, Christophe, Pommier, Yves, Cushman, Mark
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033654/
https://ncbi.nlm.nih.gov/pubmed/24800942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500294a
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