Genetic Incorporation of Histidine Derivatives Using an Engineered Pyrrolysyl-tRNA Synthetase

[Image: see text] A polyspecific amber suppressor aminoacyl-tRNA synthetase/tRNA pair was evolved that genetically encodes a series of histidine analogues in both Escherichia coli and mammalian cells. In combination with tRNA(CUA)(Pyl), a pyrrolysyl-tRNA synthetase mutant was able to site-specifical...

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Bibliographic Details
Main Authors: Xiao, Han, Peters, Francis B., Yang, Peng-Yu, Reed, Sean, Chittuluru, Johnathan R., Schultz, Peter G.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033645/
https://ncbi.nlm.nih.gov/pubmed/24506189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500032c
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