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Genetic Incorporation of Histidine Derivatives Using an Engineered Pyrrolysyl-tRNA Synthetase
[Image: see text] A polyspecific amber suppressor aminoacyl-tRNA synthetase/tRNA pair was evolved that genetically encodes a series of histidine analogues in both Escherichia coli and mammalian cells. In combination with tRNA(CUA)(Pyl), a pyrrolysyl-tRNA synthetase mutant was able to site-specifical...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American
Chemical
Society
2014
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4033645/ https://ncbi.nlm.nih.gov/pubmed/24506189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb500032c |
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