Inflammasome Activation by Cystine Crystals: Implications for the Pathogenesis of Cystinosis

Intralysosomal cystine crystal accumulation, due to mutations in the CTNS gene, is a hallmark of nephropathic cystinosis, but the role of these crystals in disease pathogenesis remains unclear. We hypothesized that, similar to other host-derived crystalline moieties, cystine crystals can induce IL-1...

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Detaylı Bibliyografya
Asıl Yazarlar: Prencipe, Giusi, Caiello, Ivan, Cherqui, Stephanie, Whisenant, Thomas, Petrini, Stefania, Emma, Francesco, De Benedetti, Fabrizio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Nephrology 2014
Konular:
Brief Communications
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033370/
https://ncbi.nlm.nih.gov/pubmed/24525029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013060653
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