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Inflammasome Activation by Cystine Crystals: Implications for the Pathogenesis of Cystinosis
Intralysosomal cystine crystal accumulation, due to mutations in the CTNS gene, is a hallmark of nephropathic cystinosis, but the role of these crystals in disease pathogenesis remains unclear. We hypothesized that, similar to other host-derived crystalline moieties, cystine crystals can induce IL-1...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Nephrology
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4033370/ https://ncbi.nlm.nih.gov/pubmed/24525029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013060653 |
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