IDH1(R132H) Mutation Increases U87 Glioma Cell Sensitivity to Radiation Therapy in Hypoxia

Objective. IDH1 codon 132 mutation (mostly Arg132His) is frequently found in gliomas and is associated with longer survival. However, it is still unclear whether IDH1 mutation renders the cell more vulnerable to current treatment, radio- and chemotherapy. Materials and Methods. We transduced U87 wit...

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Main Authors: Wang, Xiao-Wei, Labussière, Marianne, Valable, Samuel, Pérès, Elodie A., Guillamo, Jean-Sébastien, Bernaudin, Myriam, Sanson, Marc
格式: Artigo
語言:Inglês
出版: Hindawi Publishing Corporation 2014
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033346/
https://ncbi.nlm.nih.gov/pubmed/24895549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/198697
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