Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

The p53 transcription factor is a potent suppressor of tumor growth. We report here an analysis of its direct transcriptional program using Global Run-On sequencing (GRO-seq). Shortly after MDM2 inhibition by Nutlin-3, low levels of p53 rapidly activate ∼200 genes, most of them not previously establ...

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Detalhes bibliográficos
Main Authors: Allen, Mary Ann, Andrysik, Zdenek, Dengler, Veronica L, Mellert, Hestia S, Guarnieri, Anna, Freeman, Justin A, Sullivan, Kelly D, Galbraith, Matthew D, Luo, Xin, Kraus, W Lee, Dowell, Robin D, Espinosa, Joaquin M
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Genes and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033189/
https://ncbi.nlm.nih.gov/pubmed/24867637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02200
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