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The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

Accumulation and aggregation of amyloid-β (Aβ) peptides in the brain trigger the development of progressive neurodegeneration and dementia associated with Alzheimer’s disease (AD). Perturbation in Aβ clearance, rather than Aβ production, is likely the cause of sporadic, late-onset AD, which accounts...

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Détails bibliographiques
Auteurs principaux: Kanekiyo, Takahisa, Bu, Guojun
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033011/
https://ncbi.nlm.nih.gov/pubmed/24904407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2014.00093
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