Role of Lipid Rafts and GM1 in the Segregation and Processing of Prion Protein

The prion protein (PrP(C)) is highly expressed within the nervous system. Similar to other GPI-anchored proteins, PrP(C) is found in lipid rafts, membrane domains enriched in cholesterol and sphingolipids. PrP(C) raft association, together with raft lipid composition, appears essential for the conve...

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Detalhes bibliográficos
Main Authors: Botto, Laura, Cunati, Diana, Coco, Silvia, Sesana, Silvia, Bulbarelli, Alessandra, Biasini, Emiliano, Colombo, Laura, Negro, Alessandro, Chiesa, Roberto, Masserini, Massimo, Palestini, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032283/
https://ncbi.nlm.nih.gov/pubmed/24859148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098344
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