Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling

We have previously shown that crushing the optic nerve induces death of retinal ganglion cells by apoptosis, but suppression of CASP2, which is predominantly activated in retinal ganglion cells, using a stably modified short interfering RNA CASP2, inhibits retinal ganglion cell apoptosis. Here, we r...

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Bibliographic Details
Main Authors: Vigneswara, Vasanthy, Akpan, Nsikan, Berry, Martin, Logan, Ann, Troy, Carol M., Ahmed, Zubair
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032097/
https://ncbi.nlm.nih.gov/pubmed/24727569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awu037
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