The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis

Liver-specific overexpression of the insulin-like growth factor 2 (IGF2) mRNA binding protein p62/IGF2BP2-2 induces a fatty liver, which highly expresses IGF2. Because IGF2 expression is elevated in patients with steatohepatitis, the aim of our study was to elucidate the role and interconnection of...

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Hauptverfasser: Laggai, Stephan, Kessler, Sonja M., Boettcher, Stefan, Lebrun, Valérie, Gemperlein, Katja, Lederer, Eva, Leclercq, Isabelle A., Mueller, Rolf, Hartmann, Rolf W., Haybaeck, Johannes, Kiemer, Alexandra K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031940/
https://ncbi.nlm.nih.gov/pubmed/24755648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M045500
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