Inhibition of Retinoic Acid Biosynthesis by the Bisdichloroacetyldiamine WIN 18,446 Markedly Suppresses Spermatogenesis and Alters Retinoid Metabolism in Mice

Knowledge of the regulation of testicular retinoic acid synthesis is crucial for understanding its role in spermatogenesis. Bisdichloroacetyldiamines strongly inhibit spermatogenesis. We reported previously that one of these compounds, WIN 18,446, potently inhibited spermatogenesis in rabbits by inh...

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Main Authors: Paik, Jisun, Haenisch, Michael, Muller, Charles H., Goldstein, Alex S., Arnold, Samuel, Isoherranen, Nina, Brabb, Thea, Treuting, Piper M., Amory, John K.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031560/
https://ncbi.nlm.nih.gov/pubmed/24711451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.540211
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