Runx1 Regulation of Pu.1 Corepressor/Coactivator Exchange Identifies Specific Molecular Targets for Leukemia Differentiation Therapy

Gene activation requires cooperative assembly of multiprotein transcription factor-coregulator complexes. Disruption to cooperative assemblage could underlie repression of tumor suppressor genes in leukemia cells. Mechanisms of cooperation and its disruption were therefore examined for PU.1 and RUNX...

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Detaylı Bibliyografya
Asıl Yazarlar: Gu, Xiaorong, Hu, Zhenbo, Ebrahem, Quteba, Crabb, John S., Mahfouz, Reda Z., Radivoyevitch, Tomas, Crabb, John W., Saunthararajah, Yogen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2014
Konular:
Molecular Bases of Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031539/
https://ncbi.nlm.nih.gov/pubmed/24695740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.562447
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