p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia

Suppression of apoptosis by TP53 mutation contributes to resistance of acute myeloid leukemia (AML) to conventional cytotoxic treatment. Using differentiation to induce irreversible cell cycle exit in AML cells could be a p53-independent treatment alternative, however, this possibility requires eval...

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Detalhes bibliográficos
Main Authors: Ng, Kwok Peng, Ebrahem, Quteba, Negrotto, Soledad, Mahfouz, Reda Z., Link, Kevin A., Hu, Zhenbo, Gu, Xiaorong, Advani, Anjali, Kalaycio, Matt, Sobecks, Ronald, Sekeres, Mikkael, Copelan, Edward, Radivoyevitch, Tomas, Maciejewski, Jaroslaw, Mulloy, James C., Saunthararajah, Yogen
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668642/
https://ncbi.nlm.nih.gov/pubmed/21701495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.159
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