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p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia

Suppression of apoptosis by TP53 mutation contributes to resistance of acute myeloid leukemia (AML) to conventional cytotoxic treatment. Using differentiation to induce irreversible cell cycle exit in AML cells could be a p53-independent treatment alternative, however, this possibility requires eval...

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Main Authors:	Ng, Kwok Peng, Ebrahem, Quteba, Negrotto, Soledad, Mahfouz, Reda Z., Link, Kevin A., Hu, Zhenbo, Gu, Xiaorong, Advani, Anjali, Kalaycio, Matt, Sobecks, Ronald, Sekeres, Mikkael, Copelan, Edward, Radivoyevitch, Tomas, Maciejewski, Jaroslaw, Mulloy, James C., Saunthararajah, Yogen
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2011
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3668642/ https://ncbi.nlm.nih.gov/pubmed/21701495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.159
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p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia

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