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p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia
Suppression of apoptosis by TP53 mutation contributes to resistance of acute myeloid leukemia (AML) to conventional cytotoxic treatment. Using differentiation to induce irreversible cell cycle exit in AML cells could be a p53-independent treatment alternative, however, this possibility requires eval...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3668642/ https://ncbi.nlm.nih.gov/pubmed/21701495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2011.159 |
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