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High cytidine deaminase expression in the liver provides sanctuary for cancer cells from decitabine treatment effects

We document for the first time that sanctuary in an organ which expresses high levels of the enzyme cytidine deaminase (CDA) is a mechanism of cancer cell resistance to cytidine analogues. This mechanism could explain why historically, cytidine analogues have not been successful chemotherapeutics ag...

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Detaylı Bibliyografya
Asıl Yazarlar: Ebrahem, Quteba, Mahfouz, Reda, Ng, Kwok Peng, Saunthararajah, Yogen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Impact Journals LLC 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3717944/
https://ncbi.nlm.nih.gov/pubmed/23087155
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