MuRF1 Negatively Regulates Pathological Cardiac Hypertrophy Through Downregulation of Calcineurin A

BACKGROUND: Muscle-specific RING finger protein-1 (MuRF1) is an E3 ligase that inhibits cardiac hypertrophy. However, how MuRF1 regulates cardiac hypertrophy and function during pressure overload (PO) remains poorly understood. We investigated the role of endogenous MuRF1 in regulating cardiac hyper...

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Main Authors: Maejima, Yasuhiro, Usui, Soichiro, Zhai, Peiyong, Takamura, Masayuki, Kaneko, Shuichi, Zablocki, Daniela, Yokota, Mitsuhiro, Isobe, Mitsuaki, Sadoshima, Junichi
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031295/
https://ncbi.nlm.nih.gov/pubmed/24526353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.113.000713
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